Region | Title | System | Version | Edition | Languages | Serial | Status |
| Sanguozhi V 三国志Ⅴ | PC | 1.0 | Baibian Zhenbaoxiang 2 | | | |
| Shenmidao II: Xingkong Duanceng (Disc 5) 神秘岛Ⅱ:星空断层 | PC | 1.0 | Budget Rerelease | | | |
| Shenmidao II: Xingkong Duanceng (Disc 4) 神秘岛Ⅱ:星空断层 | PC | 1.0 | Budget Rerelease | | | |
| Shenmidao II: Xingkong Duanceng (Disc 3) 神秘岛Ⅱ:星空断层 | PC | 1.0 | Budget Rerelease | | | |
| Shenmidao II: Xingkong Duanceng (Disc 2) 神秘岛Ⅱ:星空断层 | PC | 1.0 | Budget Rerelease | | | |
| Shenmidao II: Xingkong Duanceng (Disc 1) 神秘岛Ⅱ:星空断层 | PC | 1.0 | Budget Rerelease | | | |
| Sega PC Greatest Hits Series Vol. 3 | PC | | Demo | | 670-11970 | |
| Spiritual Soul スピリチュアル ソウル | PC | | Drama CD Tenpu-ban | | | |
| Shiji Diguo III: Qunqiu Zhengba 世紀帝國Ⅲ:群酋爭霸 | PC | 1.0 | Huangjinban, Wanquanban | | 0812 Part No. X12-89683-02, 0906 Part No. X12-89683-01 | |
| Shiji Diguo III (Disc 3) (Youxi Guangdie) 世紀帝國Ⅲ | PC | 1.12 | Huangjinban, Wanquanban | | 0812 Part No. X18-45749-01, 1005 Part No. X11-47258 | |
| Shiji Diguo III (Disc 2) (Youxi Guangdie) 世紀帝國Ⅲ | PC | 1.12 | Huangjinban, Wanquanban | | 0812 Part No. X18-45748-01, 1005 Part No. X11-47255 | |
| Sanguozhi X (Anzhuang Guangdie) 三國志 X | PC | 1.0.3.4 | Koei the Best | | 09.10.01021 | |
| Super Games for Windows: Volume II | PC | | Original | | | |
| Sub Command (Disc 2) Sub Command: Akula Seawolf 688(I) / 潛艇指揮官 | PC | 0.1.0.0 | Original | | 1430817 | |
| Sub Command (Disc 1) Sub Command: Akula Seawolf 688(I) / 潛艇指揮官 | PC | 0.1.0.0 | Original | | 1430807 | |
| Space Adventure Cobra: Kokuryuuou no Densetsu コブラ ~黒竜王の伝説~ | PCE | | Original | | HCD8004 | |
| Space Adventure Cobra II: Densetsu no Otoko コブラⅡ ~伝説の男~ | PCE | | Original | | HCD1014 | |
| SimCity 4 Deluxe (Disc 1) シムシティ4 デラックス | PC | 1.1.613.0 | Original | | EMW-4134 | |
| SimCity 2000: CD Collection 模擬城市2000世紀光碟大補貼 | PC | 1.0 | Original | | 0026-000-060-A | |
| The Silver Case シルバー事件 | PC | | Original | | | |
| Shuangxing Wuyu 双星物语 | PC | | Original | | | |
| Shock Price 500 Game Series: Igo SHOCK PRICE 500 GAME SERIES 囲碁 | PC | | Original | | SSRX 3038 | |
| Shock Price 500 Game Series: Hit the Block SHOCK PRICE 500 GAME SERIES ヒット・ザ・ブロック | PC | | Original | | SSRX 3018 | |
| Shock Price 500 Game Series: Chu-Chu Tataki SHOCK PRICE 500 GAME SERIES チュウチュウたたき | PC | | Original | | SSRX 3016 | |
| Shock Price 500 Game Series: Black-Jack SHOCK PRICE 500 GAME SERIES ブラックジャック | PC | | Original | | SSRX 3008 | |
| Shisan Zhiju 十三支局 | PC | | Original | | 917311 | |
| Shenmidao III: Fangzhu (Disc 1) 神秘岛Ⅲ:放逐 | PC | 1.22LC (172) | Original | | | |
| Shenmidao III: Fangzhu (Youxi Zhizuo Neimu) 神秘岛Ⅲ:放逐 | PC | | Original | | | |
| Shengzhan Qunyingzhuan: Shensheng Guodu 圣战群英传:神圣国度 | PC | 1.0 | Original | | | |
| Separate Hearts 散碎的原色 | PC | | Original | | CV022 | |
| Segata Sanshirou: Choujin Densetsu せがた三四郎 超人伝説 | PC | | Original | | HCJ-0346 | |
| SeaMail: Baby Gillman-hen: Ningen Kankei Shuufuku Hozen Pet シーメール 〈ベビーギルマン編〉 人間関係修復保全ペット | PC | 1.0 | Original | | VPC-0100 | |
| Screen Club: Pocket Monsters スクリーンクラブ ポケットモンスター | PC | | Original | | | |
| Sanguozhi VIII 三国志Ⅷ | PC | 1.0 | Original | | | |
| Sanguozhi VII 三国志Ⅶ | PC | 1.0 | Original | | 5302.30124.012 | |
| Sanguozhi IX (Youxipan) 三国志Ⅸ | PC | 1.0 | Original | | | |
| Sanguozhi IX (Anzhuangpan) 三国志Ⅸ | PC | 1.0 | Original | | | |
| Sanguozhi Internet Wangjiwangluban 三國志 Internet 網際網路版 | PC | 1.01 | Original | | | |
| Sangokushi VII 三國志Ⅶ | PC | 1.0 | Original | | KN12-34101 | |
| Sangokushi VI 三國志Ⅵ | PC | 1.0 | Original | | KN11-97101 | |
| Sangokushi V Power-Up Kit 三國志Ⅴ パワーアップキット | PC | 1.0 | Original | | KN11-30103 | |
| Sangokushi V 三國志Ⅴ | PC | 1.0 | Original | | KN11-00106 | |
| Sangokushi V 三國志Ⅴ | PC-98 | | Original | | KN11-00103 | |
| Sangokushi V 三國志Ⅴ | PC-98 | | Original | | KN11-00103 | |
| Sangokushi Gekiten 三國志撃天 | PC | | Original | | | |
| S.W.I.N.E. (Disc 1) 猪兔大战 | PC | 1.2 | Original | | | |
| S.W.I.N.E. (PlayDisk) 猪兔大战 | PC | 1.2 | Original | | | |
| Sangokushi X (Game Disc) 三國志Ⅹ | PC | 1.0 | Original, Anniversary Box | | KOEI-19623B | |
| Sangokushi X (Install Disc) 三國志Ⅹ | PC | 1.0 | Original, Anniversary Box | | KOEI-19623A | |
| Soldier of Fortune II: Double Helix (Disc 2) 傭兵戰場Ⅱ | PC | | Original, Bundle Version Creative Labs OEM | | 3002648AU, 31147.102.US | |
| The Secret of Monkey Island | PC | 2.3 | Original, Bundle Version OEM | | 2147010-590001 / I 042 | |
| SimCity 3000 シムシティ3000 | PC | 1.0.557.0 | Original, DigiCube PC, Shokaiban | | DWOKD-00046, EMW-4047 | |
| SimCity 4 Deluxe (Disc 2) シムシティ4 デラックス | PC | 1.1.613.0 | Original, EA Best Hits | | EMW-4134 | |
| Sheep シープ | PC | 1.0.0.1 | Original, Game Fan 1980 | | GFM-19005 | |
| Sangokushi: Returns 三國志 リターンズ | PC | 1.0 | Original, Koei Teiban Series | | KN10-98102, KN11-06102 | |
| The Seventh Seal: The Resurrection of the Dark Lord (Disc 2) 第七封印 魔神苏醒第七封印:魔神甦醒 | PC | 2.0.0.0 | Original, Limited Edition | | | |
| SimCity 4 (Disc 1) 模擬城市:福爾摩沙 | PC | 1.0.233.0 | Original, PC Game Bundle | | | |
| Shan Yu E 善與惡 | PC | 1.0.0.1 | Original, Quanzhongwen Wanzhengban | | | |
| Sanguozhi 11 Weili Jiaqiangban 三國志11 威力加強版 | PC | 1.1 | Original, Sanguozhi 11 with Weili Jiaqiangban | | 07.01.01021 | |
| Sanguozhi 11 (Anzhuang Guangdie) 三國志11 | PC | 1.0 | Original, Sanguozhi 11 with Weili Jiaqiangban, Tecmo Koei the Best | | 06.07.01021 | |
| Sanguozhi 11 (Youxi Guangdie) 三國志11 | PC | 1.0 | Original, Sanguozhi 11 with Weili Jiaqiangban, Tecmo Koei the Best | | 06.07.01022 | |
| Sheng-Hua Weiji 3: Fuchou Nüshen 生化危机3:复仇女神 | PC | | Original, Sheng-Hua Weiji Xilie Daheji | | | |
| Sheng-Hua Weiji 2 Baijinban (Claire) 生化危机2 白金版 | PC | | Original, Sheng-Hua Weiji Xilie Daheji | | | |
| Sheng-Hua Weiji 2 Baijinban (Leon Jingguan) 生化危机2 白金版 | PC | | Original, Sheng-Hua Weiji Xilie Daheji | | | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 4) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02560 | |
| Sakura Taisen 2: Kimi, Shinitamou Koto Nakare (Install Disc 5) サクラ大戦2 ~君、死にたもうことなかれ~ | PC | 1.0.0.0 | Original, Shokai Genteiban | | 673-02561 | |
| Star Wars: Rebel Assault II: The Hidden Empire (Disc 2) スターウォーズ レベルアサルト2 | PC | FR1.14, WF1.10 | Original, Special Pack | | | |
| The Sims 2: Happy Holiday Stuff 模擬市民2:冬季派對組合 | PC | | Original, The Sims 2: Glamour Life Stuff + Happy Holiday Stuff Compilation | | 1527707 | |
| Sid Meier's Civilization II シヴィライゼーションⅡ | PC | 2.11J | Original, Value Pack | | | |
| Shiji Diguo III: Yazhou Wangchao 世紀帝國Ⅲ:亞洲王朝 | PC | 1.0 | Original, Wanquanban | | 0812 Part No. X13-94748-02, 1107 Part No. X13-94748-01 | |
| Sid Meier's Civilization II シヴィライゼーションⅡ | PC | 2.11J | PC Game Best Series Platinum Selection, Premium Pack (PC Game Best Series Platinum Selection) | | | |
| Sega's Trident Sampler Disc | PC | | PC Hardware Bundle | | | |
| Sega Worldwide Soccer PC セガワールドワイドサッカーPC | PC | 1.09J | PCHome | | 506-9781 | |
| Star Wars: Rogue Squadron 3D | PC | 1.3 | Rerelease | | 6521830 | |
| SimTown シムタウン | PC | | Rerelease | | WIC-5126 | |
| Sakura Taisen (Disc 3) サクラ大戦 | PC | | Shokai Genteiban, Fukyuuban | | 673-00192, 673-01921 | |
| Sakura Taisen (Disc 2) サクラ大戦 | PC | | Shokai Genteiban, Fukyuuban | | 673-00191, 673-01920 | |
| Sakura Taisen (Disc 1) サクラ大戦 | PC | | Shokai Genteiban, Fukyuuban | | 673-00190, 673-01919 | |
| Sonic R 索尼克R | PC | | Sonic | | | |
| Sonic CD 索尼克CD | PC | 1.0 | Sonic | | | |
| Sonic & Knuckles 索尼克与纳克鲁斯 | PC | | Sonic | | | |
| Sega PC Greatest Hits Series Vol. 2 | PC | | Taikenban, PC Game Bundle | | 670-10528 | |
| Starflight II Starflight 2: Trade Routes of the Cloud Nebula | PC | | Top Ten Pak II | | 7588 | |